Invention Grant
- Patent Title: Pyridine derivatives and their use as sodium channel activators
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Application No.: US17951640Application Date: 2022-09-23
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Publication No.: US12054486B2Publication Date: 2024-08-06
- Inventor: Verner Alexander Lofstrand , Jung Yun Kim , Helen Clement , Kristen Nicole Burford , Paul Charifson , Shawn Johnstone , Juliette Sabbatani , Jan Felix Scholtes , Wei Zhang , Shaoyi Sun
- Applicant: Xenon Pharmaceuticals Inc.
- Applicant Address: CA Burnaby
- Assignee: Xenon Pharmaceuticals Inc.
- Current Assignee: Xenon Pharmaceuticals Inc.
- Current Assignee Address: CA Burnaby
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D401/04 ; C07D401/14 ; C07D413/14 ; C07D487/04 ; C07D491/052

Abstract:
The present disclosure is directed to compounds of formula (1):
wherein X, Y, R1, R2 and R3 are as described herein, as stereoisomers, enantiomers or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, and pharmaceutical compositions comprising the compounds of formula (I), as described herein, which are useful as voltage-gated sodium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.
wherein X, Y, R1, R2 and R3 are as described herein, as stereoisomers, enantiomers or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof, and pharmaceutical compositions comprising the compounds of formula (I), as described herein, which are useful as voltage-gated sodium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy.
Public/Granted literature
- US20230144095A1 PYRIDINE DERIVATIVES AND THEIR USE AS SODIUM CHANNEL ACTIVATORS Public/Granted day:2023-05-11
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