Invention Grant
- Patent Title: Highly active agonistic CD4 binding site anti-HIV antibodies (HAADS) comprising modified CDRH2 regions that improve contact with GP120
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Application No.: US18046481Application Date: 2022-10-13
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Publication No.: US12054538B2Publication Date: 2024-08-06
- Inventor: Ron Diskin , Pamela J. Bjorkman , Michel Nussenzweig , Johannes Scheid
- Applicant: California Institute of Technology , The Rockefeller University
- Applicant Address: US CA Pasadena
- Assignee: California Institute of Technology,The Rockefeller University
- Current Assignee: California Institute of Technology,The Rockefeller University
- Current Assignee Address: US CA Pasadena; US NY New York
- Agency: Fox Rothschild LLP
- The original application number of the division: US16786821 2020.02.10
- Main IPC: C07K16/10
- IPC: C07K16/10
Abstract:
Embodiments of the present invention are directed to compositions and methods for anti-HIV (anti-CD4 binding site) potent VRC01-like (PVL) antibodies targeted to gp120 having an amino acid substitution at a residue in the anti-CD4 binding site PVL antibody that is equivalent to Phe43 in CD4, these antibodies having improved potency and breadth.
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