Invention Grant
- Patent Title: Anti-BAFFR antibody formulations and methods of use thereof
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Application No.: US17127755Application Date: 2020-12-18
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Publication No.: US12054555B2Publication Date: 2024-08-06
- Inventor: Marta Cosenza , Christoph Heusser , Julia Neugebauer , Eveline Schaadt , Stefanie Urlinger , Maximilian Woisetschlaeger
- Applicant: NOVARTIS AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent David Goetz
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K9/00 ; A61K9/08 ; A61K9/19 ; A61K9/20 ; A61K39/395 ; A61K47/10 ; A61K47/18 ; A61K47/26 ; C07K14/705 ; A61K39/00

Abstract:
Anti-BAFFR antibodies are formulated as lyophilisate or liquid formulation. The lyophilisates can be reconstituted to give a solution with a high concentration of the antibody active ingredient for delivery to a patient without high levels of antibody aggregation. The lyophilisate can be reconstituted with an aqueous reconstituent to provide an aqueous composition in which the antibody has a concentration of at least 50 mg/ml. The lyophilisate or aqueous pharmaceutical composition may include one or more of a sugar, a buffering agent, a surfactant, and/or a free amino acid.
Public/Granted literature
- US20210269540A1 ANTIBODY FORMULATION Public/Granted day:2021-09-02
Information query