Invention Grant
- Patent Title: Bifunctional molecules recruiting antibodies and targeting cancer cells
-
Application No.: US16650078Application Date: 2017-12-29
-
Publication No.: US12054560B2Publication Date: 2024-08-06
- Inventor: Zhimeng Wu , Zhifang Zhou , Haofei Hong
- Applicant: JIANGNAN UNIVERSITY
- Applicant Address: CN Jiangsu
- Assignee: JIANGNAN UNIVERSITY
- Current Assignee: JIANGNAN UNIVERSITY
- Current Assignee Address: CN Jiangsu
- Agency: MagStone Law, LLP
- Agent Enshan Hong
- International Application: PCT/CN2017/119779 2017.12.29
- International Announcement: WO2019/127346A 2019.07.04
- Date entered country: 2020-03-24
- Main IPC: C07K16/44
- IPC: C07K16/44 ; A61K47/60 ; A61K47/65

Abstract:
The present invention belonging to the technical field of biopharmaceutical discloses bifunctional molecules which are used to recruit antibodies and target tumor cells. The bifunctional molecules in the present invention comprise at least one recruitment moiety capable of binding to the existing antibodies in the body and a targeting moiety capable of selectively binding to the tumor cell. The compounds according to the invention selectively bind to the surface of the cancer cells, and recruit the existing antibodies through the recruitment moiety, and mediate the humoral and cellular immune responses to the cancer cell in the patient. According to this physiological function of the compounds according to the invention, cancer cells can be immunoregulated, which provides a new strategy for tumor immunotherapy.
Public/Granted literature
- US20210198381A1 Bifunctionnal Molecules Recruiting Antibodies and Targeting Cancer Cells Public/Granted day:2021-07-01
Information query