Invention Grant
- Patent Title: Modified AAV constructs and uses thereof
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Application No.: US17316769Application Date: 2021-05-11
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Publication No.: US12054715B2Publication Date: 2024-08-06
- Inventor: Guangping Gao , Jun Xie , Phillip D. Zamore
- Applicant: University of Massachusetts
- Applicant Address: US MA Boston
- Assignee: University of Massachusetts
- Current Assignee: University of Massachusetts
- Current Assignee Address: US MA Boston
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: C12N15/113
- IPC: C12N15/113 ; A61K31/713 ; C12N15/11 ; C12N15/86 ; C12Q1/68
Abstract:
The present disclosure relates to the field of rAAV delivery of transgenes. In some aspects, the disclosure relates to RNAi. Provided herein are recombinant adeno-associated virus (rAAV) vectors comprising modified ITRs. In some embodiments, the modified ITRs comprise a sequence encoding a shRNA, miRNA, or AmiRNA.
Public/Granted literature
- US20210340539A1 MODIFIED AAV CONSTRUCTS AND USES THEREOF Public/Granted day:2021-11-04
Information query
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