An efficient and robust high-speed neural networks for cell image classification is described herein. The neural networks for cell image classification utilize a difference between soft-max scores to determine if a cell is ambiguous or not. If the cell is ambiguous, then the class is classified in a pseudo class, and if the cell is not ambiguous, the cell is classified in the class corresponding to the highest class score. The neural networks for cell image classification enable a high speed, high accuracy and high recall implementation.