Invention Grant
- Patent Title: Methods of inhibiting viruses using compositions targeting TSG101-ubiquitin interaction
-
Application No.: US16342695Application Date: 2017-10-30
-
Publication No.: US12059413B2Publication Date: 2024-08-13
- Inventor: Carol Carter , Lorna Erlich , Nico Tjandra , Madeleine Davison
- Applicant: The Research Foundation for the State University of New York , THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US NY Albany
- Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK,THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- Current Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK,THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- Current Assignee Address: US NY Albany; US MD Bethesda
- Agent Gary J. Gershik
- International Application: PCT/US2017/059111 2017.10.30
- International Announcement: WO2018/085208A 2018.05.11
- Date entered country: 2019-04-17
- Main IPC: A61K31/4439
- IPC: A61K31/4439 ; G01N33/569
Abstract:
The present invention provides a method of inhibiting release of a virus from a cell, comprising contacting the cell with a compound that binds an ubiquitin E2 variant (UEV) domain of a cellular polypeptide, or fragment thereof, with an affinity sufficient to inhibit or disrupt the binding of the cellular polypeptide, or fragment thereof, to ubiquitin.
Public/Granted literature
- US20200038388A1 METHODS OF INHIBITING VIRUSES USING COMPOSITIONS TARGETING TSG101-UBIQUITIN INTERACTION Public/Granted day:2020-02-06
Information query
IPC分类:
