Invention Grant
- Patent Title: Scalable chromatography process for purification of human cytomegalovirus
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Application No.: US17046871Application Date: 2019-04-19
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Publication No.: US12060583B2Publication Date: 2024-08-13
- Inventor: Adam Kristopeit , Janelle Konietzko , Wanli Ma , Katherine Phillips , Andrew Swartz , Sheng-Ching Wang , Marc D. Wenger , Matthew Woodling , Tiago Matos
- Applicant: Merck Sharp & Dohme LLC
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme LLC
- Current Assignee: Merck Sharp & Dohme LLC
- Current Assignee Address: US NJ Rahway
- Agent Nichole M. Valeyko; Alysia Finnegan
- International Application: PCT/US2019/028216 2019.04.19
- International Announcement: WO2019/209632A 2019.10.31
- Date entered country: 2020-10-12
- Main IPC: B01D15/36
- IPC: B01D15/36 ; A61K39/12 ; A61K39/245 ; C12N5/079 ; C12N7/02
Abstract:
The present invention relates to a scalable process for the purification of human cytomegalovirus particles from cell culture medium. In particular, the process involves a two step chromatography process starting with an anion exchange chromatography step followed by a polishing chromatography step selected from mixed mode chromatography or cation exchange chromatography.
Public/Granted literature
- US20210047626A1 SCALABLE CHROMATOGRAPHY PROCESS FOR PURIFICATION OF HUMAN CYTOMEGALOVIRUS Public/Granted day:2021-02-18
Information query
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