- Patent Title: Ligand discovery and gene delivery via retroviral surface display
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Application No.: US16826665Application Date: 2020-03-23
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Publication No.: US12061187B2Publication Date: 2024-08-13
- Inventor: Michael Birnbaum , Connor Dobson
- Applicant: Massachusetts Institute of Technology
- Applicant Address: US MA Cambridge
- Assignee: Massachusetts Institute of Technology
- Current Assignee: Massachusetts Institute of Technology
- Current Assignee Address: US MA Cambridge
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: G01N33/50
- IPC: G01N33/50 ; C07K14/005 ; C07K14/47 ; C07K14/54 ; C07K14/705 ; C07K14/74 ; C07K16/28 ; C12N15/86
Abstract:
Compositions of retroviruses and methods of using the same for gene delivery, wherein the retroviruses comprise a viral envelope protein comprising at least one mutation that diminishes its native function, a non-viral membrane-bound protein comprising a membrane-bound domain and an extracellular targeting domain.
Public/Granted literature
- US20200371088A1 LIGAND DISCOVERY AND GENE DELIVERY VIA RETROVIRAL SURFACE DISPLAY Public/Granted day:2020-11-26
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