A system can selectively synchronize content based on synchronization settings. In some examples, a client stores a local tree representing a local set of content items associated with an account on a content management system, the local tree including respective local nodes corresponding to the local set of content items. The client stores a remote tree representing a remote set of content items associated with the account, the remote set being stored at the content management system and including respective remote nodes corresponding to the remote set of content items. The client receives a synchronization setting disabling local storage of the content item. In response, the client deletes a local copy of the content item, removes a corresponding local node from the local tree, and adds, to a remote node on the remote tree, an attribute indicating that local storage of the content item has been disabled.