Radio frequency (RF) communication systems with coexistence management are provided herein. In certain embodiments, a method of coexistence management in a mobile device includes processing a wireless local area network (WLAN) observation signal to generate WLAN observation data using a WLAN observation channel of a WLAN transceiver, processing an RF cellular receive signal to generate a digital baseband cellular receive signal using a cellular receive channel of a cellular transceiver, processing a cellular observation signal to generate cellular observation data using a cellular observation channel of the cellular transceiver, and compensating the digital baseband cellular receive signal for RF signal leakage based on the WLAN observation data and on the cellular observation data using a discrete time cancellation circuit of the cellular transceiver.