Circadian stimulus illumination control systems and methods are disclosed. Embodiments include a control system providing selection of a preset circadian stimulus profile, including a desired circadian stimulus level for setpoint times, for example, including a color temperature and brightness level for each setpoint time to simulate local natural sunlight conditions or a different selected lighting and/or stimulus condition. The control system wirelessly transmits information for the setpoints of the profile to lighting devices, which incrementally transition the color temperature and dimming of the lighting device between the profile setpoints.