Provided by the present invention is a reusable stapler comprising an adapter and a handle, the adapter being detachably connected to the handle. The adapter is a disposable component. The handle can be repeatedly used after being sterilized. The handle comprises a frame and an assembly/disassembly dial button, the assembly/disassembly button being mounted on the frame. The adapter comprises a center rod sleeve, the end of the center rod sleeve having a pair of bulges. The assembly/disassembly button is configured to control the detachable connection between the adapter and the handle. The handle can be repeatedly used after being sterilized, thereby reducing the surgery cost. The solution of detachable adapter provided by the present invention is reliable, simple, and convenient to operate, and can effectively implement the assembly and disassembly of the adapter.