Disclosed are systems and processes related to cardiopulmonary resuscitation (CPR). One embodiment of the system comprises an inspiration chamber and an expiration chamber, which work cooperatively to provide gas (e.g., Oxygen (O2)) to a subject (e.g., human patient) during inspiration and extract and expel expired gas (e.g., Carbon Dioxide (CO2)) from the subject during expiration as a medical professional applies CPR to the subject. In other words, this disclosure provides systems and processes that allow for substantially synchronous chest compressions with positive pressure active inspirations and, also, substantially synchronous chest decompressions with negative pressure active expirations.