Invention Grant
- Patent Title: AAV vectors targeted to oligodendrocytes
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Application No.: US16511913Application Date: 2019-07-15
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Publication No.: US12076351B2Publication Date: 2024-09-03
- Inventor: Thomas McCown , Steven Gray
- Applicant: The University of North Carolina at Chapel Hill
- Applicant Address: US NC Chapel Hill
- Assignee: The University of North Carolina at Chapel Hill
- Current Assignee: The University of North Carolina at Chapel Hill
- Current Assignee Address: US NC Chapel Hill
- Agency: Myers Bigel, P.A.
- The original application number of the division: US15488966 2017.04.17
- Main IPC: C12N15/86
- IPC: C12N15/86 ; A61K9/00 ; A61K35/76 ; C07K14/005 ; C12N7/00 ; A61K39/23 ; C07K14/015 ; C12N15/864
Abstract:
The invention relates to chimeric AAV capsids targeted to oligodendrocytes and virus vectors comprising the same. The invention further relates to methods of delivering a nucleic acid of interest to an oligodendrocyte in vitro and in vivo, methods of delivering a nucleic acid of interest to an area of the CNS bordering a compromised blood-brain barrier, and methods of treating disorders associated with oligodendrocyte dysfunction using the AAV capsids and virus vectors of the invention.
Public/Granted literature
- US20190328804A1 AAV Vectors Targeted to Oligodendrocytes Public/Granted day:2019-10-31
Information query
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