Invention Grant
- Patent Title: Compositions and methods for enhancing production, growth, spread, or oncolytic and immunotherapeutic efficacy of interferon-sensitive viruses
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Application No.: US16763013Application Date: 2018-11-23
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Publication No.: US12076353B2Publication Date: 2024-09-03
- Inventor: Jean-Simon Diallo , Mohammed Selman , Rozanne Arulanandam , Nicole Elise Forbes , Ramya Krishnan
- Applicant: Ottawa Hospital Research Institute
- Applicant Address: CA Ottawa
- Assignee: OTTAWA HOSPITAL RESEARCH INSTITUTE
- Current Assignee: OTTAWA HOSPITAL RESEARCH INSTITUTE
- Current Assignee Address: CA Ottawa
- Agency: Bereskin & Parr LLP/S.E.N.C.R.L., s.r.l.
- Agent Dominique Lambert
- International Application: PCT/CA2018/051492 2018.11.23
- International Announcement: WO2019/100163A 2019.05.31
- Date entered country: 2020-05-11
- Main IPC: C12N7/00
- IPC: C12N7/00 ; A61K31/225 ; A61K35/766 ; A61P35/00 ; C07C69/60 ; A61K39/00
Abstract:
Provided herein are fumaric and maleic acid-containing compounds, compositions comprising the same and methods for using such compounds to enhance production, growth, spread or titer of interferon-sensitive viruses in cells, particularly cancer and tumor cells. Also provided are methods of treating tumors or cancers in a subject by administering the compounds and compositions.
Public/Granted literature
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