Invention Grant
- Patent Title: Humanized influenza monoclonal antibodies and methods of use thereof
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Application No.: US17405748Application Date: 2021-08-18
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Publication No.: US12076390B2Publication Date: 2024-09-03
- Inventor: Wayne A. Marasco
- Applicant: Dana-Farber Cancer Institute, Inc.
- Applicant Address: US MA Boston
- Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee Address: US MA Boston
- Agency: Baker Donelson
- The original application number of the division: US15564897
- Main IPC: A61K39/145
- IPC: A61K39/145 ; A61P31/16 ; C07K16/10 ; A61K39/00
Abstract:
The present invention provides structural determinants important for binding to the stem domain of the HA protein of influenza virus, and methods of use thereof for production of high affinity neutralizing influenza virus antibodies based upon these determinants. The present invention further provides tools for determining the efficacy of an influenza virus vaccine. The present invention further provides a molecular signature useful for determining the efficacy of an influenza virus vaccine in a subject, or for predicting prior immunologic exposure or antigen responsiveness to vaccine or influenza virus infection.
Public/Granted literature
- US20220054624A1 HUMANIZED INFLUENZA MONOCLONAL ANTIBODIES AND METHODS OF USE THEREOF Public/Granted day:2022-02-24
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