Invention Grant
- Patent Title: Method for adapting influenza viruses to Vero cells
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Application No.: US18177413Application Date: 2023-03-02
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Publication No.: US12076391B2Publication Date: 2024-09-03
- Inventor: Yi Zhang , Yuhe Yan , Xu Zhang , Thomas Anthony Coton
- Applicant: YISHENG BIOPHARMA (SINGAPORE) PTE. LTD.
- Applicant Address: SG Singapore
- Assignee: Yisheng Biopharma (Singapore) Pte Ltd
- Current Assignee: Yisheng Biopharma (Singapore) Pte Ltd
- Current Assignee Address: SG Singapore
- Agency: Bozicevic, Field & Francis LLP
- Agent Shweta Chandra
- Main IPC: A61K39/145
- IPC: A61K39/145 ; A61K39/00 ; A61K39/12 ; C12N5/00 ; C12N7/00

Abstract:
A method for adapting an influenza virus to Vero cells is provided. The method comprises infecting Vero cells with the influenza virus, cultivating the infected Vero cells, harvesting influenza viruses of each passage, wherein infectious dose of the influenza viruses of one passage is greater than or equal to infectious dose of the influenza viruses of a previous passage. The present disclosure also relates to a composition. Said composition comprises polyriboinosinic acid-polyribocytidylic acid, at least one antibiotic or polyamide compound, at least one positive ion, influenza viruses and/or influenza antigens, wherein said influenza viruses and/or influenza antigens are acquired from Vero cell adapted influenza viruses.
Public/Granted literature
- US20230310578A1 METHOD FOR ADAPTING INFLUENZA VIRUSES TO VERO CELLS Public/Granted day:2023-10-05
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