A device for sealing and securing a catheter at its insertion site in order to provide for optimum safe catheter function, and to achieve maximum catheter longevity/dwell time is described. The sterile seal achieved by this device fully protects the catheter and its insertion site from external contamination. The unique sterile seal also functions to fully stabilize and secure the catheter, thereby minimizing traumatic catheter injury and loss. A means of continuously viewing the insertion site is also provided, as well as mechanisms for maintaining sterility of the sterile chamber that is formed around the catheter insertion site by the integrated sealing and securing device. Together these features allow for improved catheter safety and function, and allow catheters to safely remain in place for an extended period of time. The need to change catheter dressings at intervals is minimized or eliminated.