A single-use valve arrangement that includes a valve housing, a diaphragm carried by the valve housing, a pressure sensor, and a controller coupled to the pressure sensor. The valve housing defines an inlet and an outlet, the inlet adapted to be fluidly connected to an outlet of a virus removal filter. The diaphragm divides the valve housing into a first chamber and a second chamber fluidly isolated from the first chamber. The pressure sensor is configured to measure a pressure change in the second chamber due to movement of the diaphragm responsive to a pressure change in the first chamber. The controller is configured to determine an actual leak rate of the filter based on the measured pressure change, the controller further configured to determine the integrity of the filter by comparing the actual leak rate to an expected leak rate of the filter.