A device for raising and lowering a spare wheel of a vehicle includes a body to be mounted to the vehicle in a fixed position. The body includes a first indented surface defining an aperture, A lifter mechanism for raising and lowering the spare wheel includes a rotatable element capable of rotating relative to the body. The rotatable element is at least partly housed in the aperture and has a second indented surface. The first and second indented surfaces are configured to mutually interfere, in order to hinder the rotation of the rotatable element relative to the body.