Invention Grant
- Patent Title: Zinc complex, preparation thereof and use thereof for trerapy of human and animal diseases
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Application No.: US17270384Application Date: 2019-08-22
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Publication No.: US12077551B2Publication Date: 2024-09-03
- Inventor: Vladimir Evgenievich Nebolsin
- Applicant: OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTIYU “Z THERAPEUTICS”
- Applicant Address: RU Moscow
- Assignee: OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTIYU “Z THERAPEUTICS”
- Current Assignee: OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTIYU “Z THERAPEUTICS”
- Current Assignee Address: RU Moscow
- Agency: BCF LLP
- Priority: RU 2018130491 2018.08.22
- International Application: PCT/RU2019/050135 2019.08.22
- International Announcement: WO2020/040670A 2020.02.27
- Date entered country: 2021-02-22
- Main IPC: C07F3/06
- IPC: C07F3/06 ; A61P17/00
Abstract:
The invention relates to a new zinc complex with gamma-L-glutamylhistamine with a metal/ligand ratio of 1/1. In particular, the invention relates to a compound of the formula
The complex according to the invention helps to restore the barrier functions of the epithelial tissue and suppresses the aberrant activity of the immune cells.
The invention also relates to the method of complex preparation and use of said zinc complex for the treatment of atopic dermatitis and other diseases associated with impaired barrier functions of epithelial tissue and the development of an aberrant inflammatory response.
The invention also relates to the use of the prepared complex for inhibiting glutaminyl cyclase.
This invention also concerns pharmaceutical compositions comprising a therapeutically effective amount of a compound of the invention.
The complex according to the invention helps to restore the barrier functions of the epithelial tissue and suppresses the aberrant activity of the immune cells.
The invention also relates to the method of complex preparation and use of said zinc complex for the treatment of atopic dermatitis and other diseases associated with impaired barrier functions of epithelial tissue and the development of an aberrant inflammatory response.
The invention also relates to the use of the prepared complex for inhibiting glutaminyl cyclase.
This invention also concerns pharmaceutical compositions comprising a therapeutically effective amount of a compound of the invention.
Public/Granted literature
- US20210246149A1 A NEW ZINC COMPLEX, PREPARATION THEREOF AND USE THEREOF FOR TRERAPY OF HUMAN AND ANIMAL DISEASES Public/Granted day:2021-08-12
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