Invention Grant
- Patent Title: Process for the preparation of 3α-hydroxy-5α-pregnan-20-one (brexanolone)
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Application No.: US17282772Application Date: 2019-10-21
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Publication No.: US12077559B2Publication Date: 2024-09-03
- Inventor: Claudio Delfrate , Davide Rigamonti , Tea Borelli , Roberto Lenna
- Applicant: INDUSTRIALE CHIMICA S.R.L
- Applicant Address: IT Milan
- Assignee: INDUSTRIALE CHIMICA S.R.L.
- Current Assignee: INDUSTRIALE CHIMICA S.R.L.
- Current Assignee Address: IT Milan
- Agency: Leason Ellis LLP
- Priority: IT 2018000009683 2018.10.22
- International Application: PCT/EP2019/078580 2019.10.21
- International Announcement: WO2020/083839A 2020.04.30
- Date entered country: 2021-04-04
- Main IPC: C07J7/00
- IPC: C07J7/00 ; C07J17/00 ; C07J33/00
Abstract:
The present invention relates to a new process for the synthesis of 3α-hydroxy-5α-pregnan-20-one, commonly known as brexanolone, wherein the corresponding cyclic 20-ketal or cyclic 20-thioketal compound of formula (IV) is deprotected with the use or iodine in an organic solvent: (I).
Public/Granted literature
- US20210388020A1 PROCESS FOR THE PREPARATION OF 3ALPHA-HYDROXY-5ALPHA-PREGNAN-20-0NE (BREXANOLONE) Public/Granted day:2021-12-16
Information query
