Invention Grant
- Patent Title: Engineered active single-polypeptide chain insulin analogs
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Application No.: US17281870Application Date: 2019-09-11
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Publication No.: US12077568B2Publication Date: 2024-09-03
- Inventor: Ke-He Ruan
- Applicant: University of Houston System
- Applicant Address: US TX Houston
- Assignee: University of Houston System
- Current Assignee: University of Houston System
- Current Assignee Address: US TX Houston
- Agency: Parker Highlander PLLC
- International Application: PCT/US2019/050637 2019.09.11
- International Announcement: WO2020/072181A 2020.04.09
- Date entered country: 2021-03-31
- Main IPC: C07K14/62
- IPC: C07K14/62 ; A61K38/00 ; A61P3/10 ; C12N15/70 ; C12N15/81 ; C12N15/85 ; C12N15/86
Abstract:
Described herein are single chain polypeptides comprising both the b- and a-chains of insulin fused to each other by a linker. Also provided are nucleic acids coding for the same, host cells expressing the same, and methods of use therefor.
Public/Granted literature
- US20210388050A1 ENGINEERED ACTIVE SINGLE-POLYPEPTIDE CHAIN INSULIN ANALOGS Public/Granted day:2021-12-16
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