- Patent Title: Polypeptide comprising aggrecan binding domain and carrying moiety
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Application No.: US17058961Application Date: 2019-05-30
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Publication No.: US12077577B2Publication Date: 2024-09-03
- Inventor: Hidetomo Kitamura , Maiko Hoshino , Yang Sun , Taichi Kuramochi , Wenjie Tu , Tomoyuki Igawa , Naoka Hironiwa , Yuki Noguchi
- Applicant: Chugai Seiyaku Kabushiki Kaisha
- Applicant Address: JP Tokyo
- Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Nixon & Vanderhye P.C.
- Priority: JP 18103233 2018.05.30
- International Application: PCT/JP2019/021463 2019.05.30
- International Announcement: WO2019/230867A 2019.12.05
- Date entered country: 2020-11-25
- Main IPC: C07K16/18
- IPC: C07K16/18 ; A61K39/00

Abstract:
The present invention provides a polypeptide comprising an antigen binding domain which binds to an antigen present in cartilage tissue, and also provides use of the polypeptide. The polypeptide of the invention is useful for penetrating and/or retaining a desired substance in the cartilage tissue for a long period. The present invention further relates to a polypeptide comprising (i) an antigen binding domain which binds to a molecule in a cartilage tissue, and (ii) a carrying moiety having an inhibiting domain that inhibits the antigen binding activity of the antigen binding domain, and having a longer half-life than that of the antigen binding domain existing alone, and a pharmaceutical composition comprising the polypeptide. The present invention further relates to methods for producing and screening for the polypeptide.
Public/Granted literature
- US20210221875A1 POLYPEPTIDE COMPRISING AGGRECAN BINDING DOMAIN AND CARRYING MOIETY Public/Granted day:2021-07-22
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