Invention Grant
- Patent Title: Variable lymphocyte receptors that target the brain extracellular matrix and methods of use
-
Application No.: US17414581Application Date: 2019-12-19
-
Publication No.: US12077609B2Publication Date: 2024-09-03
- Inventor: Eric V. Shusta , Benjamin Umlauf , Brantley Herrin , Paul Clark , John Kuo
- Applicant: Wisconsin Alumni Research Foundation , Emory University
- Applicant Address: US WI Madison
- Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION,EMORY UNIVERSITY
- Current Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION,EMORY UNIVERSITY
- Current Assignee Address: US WI Madison; US GA Atlanta
- Agency: Quarles & Brady, LLP
- International Application: PCT/US2019/067579 2019.12.19
- International Announcement: WO2020/132301A 2020.06.25
- Date entered country: 2021-06-16
- Main IPC: C07K7/08
- IPC: C07K7/08 ; A61K38/00 ; A61K45/06 ; A61P35/00 ; C07K7/06 ; C12N15/86
Abstract:
The present disclosure provides isolated polypeptides comprising variable lymphocyte receptors that specifically bind the brain extracellular matrix, compositions, and methods of use. Methods of using the variable lymphocyte receptors for the detection and treatment of disease or injury, specifically, for example, cancers including glioblastoma are provided.
Information query
