Invention Grant
- Patent Title: Methods of generating human inner ear sensory epithelia and sensory neurons
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Application No.: US16989554Application Date: 2020-08-10
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Publication No.: US12077778B2Publication Date: 2024-09-03
- Inventor: Karl R. Koehler , Eri Hashino
- Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
- Applicant Address: US IN Indianapolis
- Assignee: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
- Current Assignee: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
- Current Assignee Address: US IN Bloomington
- Agency: Quarles & Brady, LLP
- The original application number of the division: US15769254
- Main IPC: C12N5/0793
- IPC: C12N5/0793 ; C12N5/0735 ; C12N5/074
Abstract:
Provided herein are methods for directing differentiation of human pluripotent stem cells into inner ear sensory epithelia and sensory neurons. More particularly, provided herein are methods for obtaining three-dimensional cultures comprising human pluripotent stem cell-derived pre-otic epithelium, otic vesicles, and inner ear sensory epithelia containing hair cells, sensory neurons, and supporting cells.
Public/Granted literature
- US20200370007A1 METHODS OF GENERATING HUMAN INNER EAR SENSORY EPITHELIA AND SENSORY NEURONS Public/Granted day:2020-11-26
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