Invention Grant
- Patent Title: Lipid-modified oligonucleotides and methods of using the same
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Application No.: US17258420Application Date: 2019-07-08
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Publication No.: US12077826B2Publication Date: 2024-09-03
- Inventor: Zev J. Gartner , David Patterson , Eric D. Chow , Robert Weber , Christopher McGinnis
- Applicant: The Regents of The University of California
- Applicant Address: US CA Oakland
- Assignee: The Regents of The University of California
- Current Assignee: The Regents of The University of California
- Current Assignee Address: US CA Oakland
- Agency: The Regents of the University of California
- International Application: PCT/US2019/040898 2019.07.08
- International Announcement: WO2020/010366A 2020.01.09
- Date entered country: 2021-01-06
- Main IPC: C12Q1/6886
- IPC: C12Q1/6886 ; C12Q1/6806

Abstract:
Disclosed are compositions comprising a first lipid-conjugated oligonucleotide comprising a first lipid moiety, a first hybridization region, and a first primer region; a second lipid-conjugated oligonucleotide comprising a second hybridization region and a second lipid moiety, wherein the second hybridization region is the reverse complement of the first hybridization region; and a third oligonucleotide comprising a second primer region, a barcode region, and a capture sequence, wherein the second primer region is the reverse complement of the first primer region; compositions comprising a lipid-conjugated DNA oligonucleotide comprising a lipid moiety, a barcode region, and a capture sequence; and composition comprising a first lipid-conjugated DNA oligonucleotide comprising a lipid moiety and a first primer region; and a second DNA oligonucleotide comprising a second primer region, a barcode region, and a capture sequence, wherein the second primer region is the reverse complement of the first primer region. Also disclosed are membranes and cells comprising such compositions and uses of such compositions.
Public/Granted literature
- US20210388447A1 LIPID-MODIFIED OLIGONUCLEOTIDES AND METHODS OF USING THE SAME Public/Granted day:2021-12-16
Information query
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