Invention Grant
- Patent Title: Methods for predicting the risk of developing pulmonary colonization/infection by
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Application No.: US16651426Application Date: 2018-09-28
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Publication No.: US12077827B2Publication Date: 2024-09-03
- Inventor: Geneviève Hery-Arnaud , Jérôme Mounier , Marlène Keravec , Stanislas Mondot , Patricia Lepage , Charles-Antoine Guilloux
- Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ DE BRETAGNE OCCIDENTALE , ETABLISSEMENT FRANCAIS DU SANG (EFS) , CENTRE HOSPITALIER REGIONSL ET UNIVERSITAIRE DE BREST , INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
- Applicant Address: FR Paris
- Assignee: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE),UNIVERSITE DE BRETAGNE OCCIDENTALE,ETABLISSEMENT FRANCAIS DU SANG (EFS),CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE BREST,INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'EVIRONNEMENT
- Current Assignee: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE),UNIVERSITE DE BRETAGNE OCCIDENTALE,ETABLISSEMENT FRANCAIS DU SANG (EFS),CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE BREST,INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'EVIRONNEMENT
- Current Assignee Address: FR Paris; FR Brest; FR La Plaine Saint Denis; FR Brest; FR Paris
- Agency: WC&F IP
- Priority: EP 306297 2017.09.29 EP 306717 2017.12.07
- International Application: PCT/EP2018/076442 2018.09.28
- International Announcement: WO2019/063783A 2019.04.04
- Date entered country: 2020-03-27
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; A61K35/741 ; C07K16/12 ; C12Q1/689 ; A61K35/00 ; A61K45/06
Abstract:
The present invention relates to methods for predicting the risk of developing pulmonary colonization/infection by P. aeruginosa. The inventors analyzed the respiratory tract microbiota from 65 patients sputum samples and compared microbiota data. The inventors found that patients that will remain uninfected from P. aeruginosa exhibited 3-fold higher abundance of Porphyromonas compared to the other groups. In particular, the present invention relates to a method for predicting the risk of developing pulmonary colonization/infection by P. aeruginosa in a subject suffering from cystic fibrosis (CF) comprising measuring the abundance of Porphyromonas genus bacteria in a biological sample obtained from said subject.
Public/Granted literature
- US20200283829A1 METHODS FOR PREDICTING THE RISK OF DEVELOPING PULMONARY COLONIZATION/INFECTION BY PSEUDOMONAS AERUGINOSA Public/Granted day:2020-09-10
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