A device for the detection of gamma rays presents a high resolution in the three-dimensional position of the impact of the gamma ray within one or more scintillation crystal blocks coupled to an array of photosensors, for the determination of the impact energy of said gamma ray, the determination of the instant in time when said impact occurred, the interaction depth and the determination of the time-of-flight. Advantageously, in said device, the scintillation crystal detection blocks are optically isolated, in such a way that the scintillation light can only exit said blocks via the output region; and the scintillation crystal detection blocks and the array of photosensors are disposed in direct optical coupling.