A quantum computing system includes a cryostat to support a low-temperature vacuum environment during operation of the quantum computing system; a quantum processor positioned in the cryostat; a first electronic control module external to the cryostat; a second electronic control module within the cryostat; at least one optical transmission line connecting the first electronic control module external to the cryostat with the second electronic control module internal to the cryostat, the optical transmission line being configured to transmit optical signals to and from the second electronic control module during operation of the quantum computing system; and a plurality of signal lines connecting the second electronic control module with the quantum processor, a first subset of the signal lines being configured to transmit microwave signals to and from the quantum processor during operation of the quantum computing system.