Systems and methods for registration of image pairs, including camera response function normalization are disclosed and include selecting a pair of images from a set of images, each of the pair of images having associated metadata, determining a camera response function for each of the images in the pair of images using the associated metadata, normalizing each camera response function for across the set of images, and applying the normalized camera response function to the pair of images. A deformation map is generated in a multi-scale process using registration parameters, to deform one of the pair of images to align with another of the pair of images. The image pairs may be selected by identifying image pairs having an overlap that exceeds an overlap threshold, having a sequential proximity in an image series satisfying a proximity threshold, and/or having estimated image capture attitudes within an attitude threshold.