Methods and systems for actively and adaptively deconstructively interfering with noise and vibration generated by medical devices. A method includes receiving, via user input, information associated with a configuration of the medical device or a physical environment proximate to the medical device. The method includes determining a signature signal for the medical device based at least on the information and sensor data from a sensor of the medical device configured to sense a characteristic of the physical environment proximate to the medical device, the signature signal representing physical attributes of the physical environment; and determining an inverted signal based on the signature signal. The method includes generating a physical representation of the inverted signal by one or more electrical or electromechanical components of the medical device, the physical representation of the inverted signal deconstructively interfering with the physical attributes of the environment represented by the signature signal.