An active noise cancelling system (20) comprising: an earphone (8′) comprising: an electro-acoustic driver (11); and at least one sensing microphone (12, 13); tunable active noise cancelling circuitry (7) operative to receive a signal from the at least one sensing microphone (12, 13), the tunable active noise cancelling circuitry (7) being pre-configured in a standard tuning for a reference ear and comprising at least one noise-control filter (14, 15); and a tuning module (24) operative to configure the earphone (8′) for an individual wearer by: comparing acoustic coupling of the earphone (8′) to the individual wearer's ear with acoustic coupling to the reference ear to determine a deviation in acoustic coupling; and using the determined deviation in acoustic coupling to modify the tunable active noise cancelling circuitry (7) by a predetermined degree based on the determined deviation in acoustic coupling.