Invention Grant
- Patent Title: Automated nucleic acid repeat count calling methods
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Application No.: US16659449Application Date: 2019-10-21
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Publication No.: US12080383B2Publication Date: 2024-09-03
- Inventor: A. Scott Patterson , Imran S. Haque , Eric A. Evans , Clement Chu
- Applicant: MYRIAD WOMEN'S HEALTH, INC.
- Applicant Address: US CA South San Francisco
- Assignee: Myriad Women's Health, Inc.
- Current Assignee: Myriad Women's Health, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Foley & Lardner LLP
- The original application number of the division: US14540334 2014.11.13
- Main IPC: G16B40/10
- IPC: G16B40/10 ; G16B20/00 ; G16B20/20 ; G16B30/00

Abstract:
The present disclosure relates to processes for determining the number of nucleic acid repeats in a DNA fragment comprising a nucleic acid repeat region. One example method may include receiving DNA size and abundance data generated by resolving DNA amplification products. A set of low-pass data may be generated by applying a low-pass filter to the DNA size and abundance data and a set of band-pass data may be generated by applying a band-pass filter to the DNA size and abundance data. A peak of the DNA size and abundance data representative of a number of nucleic acid repeats in the DNA may be identified based on peaks identified from the low-pass data and the band-pass data.
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