Disclosed are a radioisotope activity surveillance system and methods. The system includes a fuel rod assembly having a plurality of nuclear fuel rods and a target assembly having a top nozzle including an orifice plate and at least one target material rod fixedly coupled to the orifice plate. The least one target material rod is slidably disposed within the fuel rod assembly. A sensing assembly defines an opening sized and configured to receive the target assembly therethrough. The sensing assembly includes a self-powered detector assembly to detect radioisotope activity of the target rod material. Also disclosed is a method for measuring a self-powered detector signal to calculate radioisotope activity of a target assembly and a method for analyzing total activity of a desired radioisotope.