Systems and methods for verifying wireless connections are provided. In one example, a method includes, at a computing system, responsive to initiating a wireless connection between a client device and a host device, generating a communication fingerprint of the client device based on at least one response characteristic of the client device, the at least one response characteristic based on a communication between the client device and the host device, the communication passing through each of a software layer of the client device and a hardware element of the client device. In this way, overall system security of a wireless connection between the host device and the client device may be increased.