Invention Grant
- Patent Title: Triazole bisphosphonate geranylgeranyl diphosphate synthase inhibitors
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Application No.: US17332324Application Date: 2021-05-27
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Publication No.: US12083137B2Publication Date: 2024-09-10
- Inventor: Sarah Holstein , David Wiemer
- Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA , UNIVERSITY OF IOWA RESEARCH FOUNDATION
- Applicant Address: US NE Lincoln
- Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA,UNIVERSITY OF IOWA RESEARCH FOUNDATION
- Current Assignee: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA,UNIVERSITY OF IOWA RESEARCH FOUNDATION
- Current Assignee Address: US NE Lincoln; US IA Iowa City
- Agency: MARSHALL, GERSTEIN & BORUN LLP
- Main IPC: A61K31/683
- IPC: A61K31/683 ; A61K45/06 ; C07F9/6518
Abstract:
Disclosed herein are inhibitors of the GGDPS enzyme, and methods for their use in treating or preventing diseases, such as multiple myeloma. The inhibitors described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof:
wherein the substituents are described.
wherein the substituents are described.
Public/Granted literature
- US20210393654A1 TRIAZOLE BISPHOSPHONATE GERANYLGERANYL DIPHOSPHATE SYNTHASE INHIBITORS Public/Granted day:2021-12-23
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