Systems and methods to providing gated in-game access based on collections and/or combinations of unique digital articles in an online gaming platform are disclosed. Exemplary implementations may execute instances of a game; manage player accounts associated with the players, including a first player account associated with a first player, wherein a first account inventory includes a first and a second unique digital article; receive, from the first player, a first action request for an in-game action that requires ownership of the first and second unique digital articles (as recorded on an immutable ledger); permit the first action request (and other similar requests) unless and until the first player is no longer the registered owner of the first and second unique digital articles.