Systems and methods relating to foreign object detection with respect to stowage compartments or other regions of a vehicle are provided. According to one example, sensor data is captured via a sensor subsystem that includes a sensor associated with each of a plurality of stowage compartments. For each of the stowage compartments, a baseline condition is identified in which foreign objects are absent from the stowage compartment. A foreign object is detected within a stowage compartment based on the sensor data received for the stowage compartment and the baseline condition identified for the stowage compartment. An indication that the foreign object is detected within the stowage compartment is output. This indication may identify the stowage compartment containing the foreign object among the plurality of stowage compartments.