A system with plurality of smart wearable and non-wearable having embedded NFC (Near Field Communication) tags, vital health sensors and UV-C germicidal irradiation sources; a computer mobile/cloud implemented platform with an artificial intelligence or machine learning powered virtual assistant; and a central cloud server is provided for prevention of spread of pathogens and for monitoring and/prediction of infection and timely intervention assistance for better health outcomes to the user, taking into account the underlying conditions of the user. The system includes a plurality of body wearables including, but not limited to, a hand glove, a footwear, a vest, a full body suit, a face mask, a footwear cover or a smart portables and at least one non-wearable portable smart device, and all of them with re-programmable NFC tags and UVGI source embedded within them, to dis-infect any surface the user desire, and to avoid touching any surfaces, and the same—each device of which having a plethora of various body health and viral monitoring sensors, embedded within them to transmit and upload data to mobile/cloud platform, to predict probability of infection and take necessary actions to provide better personalized health outcomes.