System and methods are described for anomaly detection and root cause analysis in database systems, such as multi-tenant environments. In one implementation, a method comprises receiving an activity signal representative of resource utilization within a multi-tenant environment; detecting a plurality of anomalies in the activity signal; computing a priority score for each of the plurality of anomalies; correlating at least a subset of the plurality of anomalies to one or more performance metrics of the multi-tenant environment; and transmitting a remediation signal to one or more devices in the multi-tenant environment based on the correlations and the priority scores.