The present invention relates to a method for establishing a communicable connection with a tire pressure monitoring system, an apparatus thereof and an electronic device. The method includes: determining several candidate protocol configurations; loading the candidate protocol configurations one by one until at least one usable configuration is determined, the usable configuration being a protocol configuration with which a communicable connection with the tire pressure monitoring system can be established; and establishing a communicable connection with the tire pressure monitoring system based on the usable configuration. By applying the method for establishing a communicable connection with a tire pressure monitoring system, a success rate of a diagnostic device entering a tire pressure monitoring system is improved without increasing hardware device costs. Connection errors do not occur frequently, thereby providing better user experience.