The personal pandemic proximity index system and method include a data ingestion pipeline configured to receive location data associated with disease-positive cases, a data processing module configured to clean and process the received data, a personal pandemic proximity module configured to determine a numerical personal pandemic proximity index value associated with an individual having an interaction at an address relative to the location data, and a graphical user interface configured to present, to a patient care team, the numerical personal pandemic proximity index value, which may include a modified workflow to limit the spread of disease.