Methods and systems are provided for fusing tissue characterization information into ultrasound images. In one example, a method includes obtaining first image data of an anatomical region of interest (ROI) of a patient, the first image data including tissue characterization information and acquired with a first imaging modality; obtaining second image data of the anatomical ROI of the patient, the second image data acquired with a second imaging modality; registering the first image data and the second image data; adjusting the second image data based on the tissue characterization information and the registration, wherein the adjusting includes filtering, adjusting colorization, adjusting brightness, and/or adjusting material appearance properties of one or more aspects of the second image data; generating a fused image from the adjusted second image data; and outputting the fused image for display and/or storage.