The invention as described herein provides methods for treating a bone of a patient, including locating a treatment volume in a bone of the patient, administering a sclerosing agent to the treatment volume, and, after administering the sclerosing agent, administering bone graft material to the treatment volume. In some embodiments, the sclerosing agent and the bone graft are administered in a minimally invasive manner using a delivery device. The placement of the delivery device and/or the administration of the sclerosing agent and/or bone graft can use imaging to guide the placement and/or administration. The patient can be a pediatric patient and the treatment volume can comprise a bone lesion, a unicameral bone cyst or an aneurysmal bone cyst.