Anatomy mannequins, models and medical simulation systems may facilitate training by rendering a realistic tactile feedback when the end user manipulates the anatomy model with a handheld tool. An anatomy model may comprise various inexpensive material arrangements to replicate the side-to-side motion friction and resistance against the insertion and manipulation of a surgical instrument in a living body soft body tissue, such as muscle or ligament layers, while ensuring sustainability of the corresponding simulator parts over at least thousands of training sessions. A mesh layer may be arranged as an interlinked mesh of elastomer strands. A soft body layer may also be arranged as a grid of flexible protruding elements. The instrument may be inserted and manipulated through the crossings of the interlinked elastomer strands and/or the recesses or channels between the flexible protruding elements to provide a tactile feedback similar to that of real surgery tool handheld manipulation.