Invention Grant
- Patent Title: Preparation method and application of biomimetic nano-protectant for detoxifying dox-induced cardiac and systemic toxicity
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Application No.: US18287463Application Date: 2022-06-27
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Publication No.: US12102690B2Publication Date: 2024-10-01
- Inventor: Yijie Chen , Mengchun Chen , Weiliang Xia , Deli Zhuge , Haiyan Zhu , Yingzheng Zhao , Qi Jiang
- Applicant: The Second Affiliated Hospital of Wenzhou Medical University
- Applicant Address: CN Wenzhou
- Assignee: THE SECOND AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY
- Current Assignee: THE SECOND AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIVERSITY
- Current Assignee Address: CN Wenzhou
- Agency: Bayramoglu Law Offices LLC
- Priority: CN 2110746762.6 2021.07.01
- International Application: PCT/CN2022/101401 2022.06.27
- International Announcement: WO2023/274105A 2023.01.05
- Date entered country: 2023-10-19
- Main IPC: A61K47/69
- IPC: A61K47/69 ; A61K47/64 ; A61P39/02
Abstract:
A preparation method and application of a biomimetic nano-protectant for detoxifying doxorubicin (DOX)-induced cardiac and systemic toxicity are provided. The preparation method comprises the following steps: obtaining and mixing DNA and protamine (Pro) to prepare DNA&Pro nanoparticles; reacting heterofunctional polyethylene glycol DSPE-PEG2000-MAL with PCM/KALA to prepare DSPE-PEG2000-PCM/KALA; inserting DSPE-PEG2000-PCM/KALA into a surface of Red Blood Cell Membrane (RBCM) to prepare PCM/KALA-RBCM; and mixing the RBCM-PCM/KALA with the DNA&Pro nanoparticles to prepare a biomimetic nano-protectant DNA&Pro@RBCM-PCM/KALA. The biomimetic nano-protectant prepared is applied to detoxification of DOX.
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