- Patent Title: Pyclen-based macrocyclic ligands, chelates thereof and uses thereof
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Application No.: US17042408Application Date: 2019-03-29
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Publication No.: US12103927B2Publication Date: 2024-10-01
- Inventor: Nadège Hamon , Maryline Beyler , Raphaël Tripier , Olivier Maury , Janah Shaya
- Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , ÉCOLE NORMALE SUPÉRIEURE DE LYON , UNIVERSITÉ CLAUDE BERNARD LYON 1 (UCBL1) , UNIVERSITÉ DE BRETAGNE OCCIDENTALE
- Applicant Address: FR Paris
- Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE,ÉCOLE NORMALE SUPÉRIEURE DE LYON,UNIVERSITÉ CLAUDE BERNARD LYON 1 (UCBL1),UNIVERSITÉ DE BRETAGNE OCCIDENTALE
- Current Assignee: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE,ÉCOLE NORMALE SUPÉRIEURE DE LYON,UNIVERSITÉ CLAUDE BERNARD LYON 1 (UCBL1),UNIVERSITÉ DE BRETAGNE OCCIDENTALE
- Current Assignee Address: FR Paris; FR Lyons; FR Villeurbanne; FR Brest
- Agency: Maier & Maier, PLLC
- Priority: EP 305380 2018.03.30
- International Application: PCT/EP2019/058066 2019.03.29
- International Announcement: WO2019/185901A 2019.10.03
- Date entered country: 2020-09-28
- Main IPC: C07D471/08
- IPC: C07D471/08 ; A61K49/00

Abstract:
A ligand of Formula (A):
or a carboxylate salt thereof; wherein Y1, Y2 and Y3 each independently represents —COOH or a picolinate of Formula (i):
wherein each R1 independently represents a chromophore group; L1, L2 and L3 each independently represents a single bond or a linker; and X1, X2 and X3 each independently represents a hydrogen atom, a coupling function or a bio-vectorizing group. Also, a process for manufacturing the ligand and to a process for manufacturing a chelate by complexation by the ligand of a rare-earth cation, preferably a lanthanide cation. Further, a use of the ligand and/or the chelate in biological imaging and/or photoluminescence imaging.
or a carboxylate salt thereof; wherein Y1, Y2 and Y3 each independently represents —COOH or a picolinate of Formula (i):
wherein each R1 independently represents a chromophore group; L1, L2 and L3 each independently represents a single bond or a linker; and X1, X2 and X3 each independently represents a hydrogen atom, a coupling function or a bio-vectorizing group. Also, a process for manufacturing the ligand and to a process for manufacturing a chelate by complexation by the ligand of a rare-earth cation, preferably a lanthanide cation. Further, a use of the ligand and/or the chelate in biological imaging and/or photoluminescence imaging.
Public/Granted literature
- US20210017180A1 PYCLEN-BASED MACROCYCLIC LIGANDS, CHELATES THEREOF AND USES THEREOF Public/Granted day:2021-01-21
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