Invention Grant
- Patent Title: Compositions and methods for synthesizing 5′-capped RNAs
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Application No.: US18408431Application Date: 2024-01-09
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Publication No.: US12103944B2Publication Date: 2024-10-01
- Inventor: Richard I. Hogrefe , Alexandre Lebedev , Anton P. McCaffrey , Dongwon Shin
- Applicant: TriLink BioTechnologies, LLC
- Applicant Address: US CA San Diego
- Assignee: TriLink BioTechnologies, LLC
- Current Assignee: TriLink BioTechnologies, LLC
- Current Assignee Address: US CA San Diego
- Agency: Kilpatrick Townsend & Stockton LLP
- Main IPC: C07H21/02
- IPC: C07H21/02 ; A23L33/13 ; A61K31/711 ; A61K31/7115 ; A61K31/712 ; C12N15/11 ; C12P19/34
Abstract:
Provided herein are methods and compositions for synthesizing 5′Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2′Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.
Public/Granted literature
- US20240158433A1 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS Public/Granted day:2024-05-16
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